University of Cape Town: NITAG-led Co-development of Model-Based Recommendations for Introduction and Implementation of New TB Vaccines

Overall, the project will enhance the utilization of model-based evidence by NITAGs during the Evidence to Recommendation (EtR) process for vaccines and immunization. Through a co-creation process anchored in modelling, the investigators will work with NITAGs from Kenya, Gambia and South Africa to develop and submit a model-based TB vaccine introduction recommendation dossier to their MoH. The work will be done through five interlinked work packages, leveraging on the extensive VACFA/NISH networks to advance TB control programmes. We have engaged and established interest from the selected NITAGs. In addition, we have consulted with key stakeholders already working in the space of TB vaccine modelling to ensure this work complements, and not duplicate ongoing studies. Outputs for this study includes TB vaccine modelled-based recommendation submitted to MOH by each NITAG, Evidence Gap Maps, a modelled-based EtR toolkit to support NITAGs with making recommendations, Libguides, and publications. Outcomes includes improved utilization of model-based evidence for decision-making by NITAGs. The impact will be smoother and more timeous introduction of novel TB vaccines in the three identified countries. The strength of this study is the co-creation approach with NITAGs and the utility of the study findings beyond just the novel TB vaccine introduction.

Programme: Discretionary Award

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